Cambridge/UK and Berlin/Germany, May 2, 2016 – Sentinel Oncology and NMI TT Pharmaservices today announced that they have received grant funding for the development of a companion diagnostic to compliment the ongoing drug development activities within Sentinel Oncology for the treatment of the Fragile X Syndrome (FXS), a genetically inherited orphan disease that manifests itself in intellectual disability, for which no treatments are currently available.

The funding, totaling more than 500k Euros over a duration of 18 months, has been awarded to their project consortium named ‘FXSFIX’, under the Eurostars program (www.eurostars-eureka.eu) of EUREKA and the European Commission for research and development performing small- and medium-sized enterprises.

Within the jointly agreed work plan, Sentinel Oncology will conduct studies in parallel with the ongoing SOL101 development activities to identify clinical markers of efficacy for use in future clinical trials of SOL101 in FXS patients. Based on promising proof of concept studies with small molecule compound SOL101, Sentinel Oncology’s candidate drug, the programme will now focus on completing a pre-clinical development package for subsequent clinical advancement of SOL101, of which the output of the FXSFIX project will be a key addition. NMI TT Pharmaservices will conduct a biomarker discovery and development programme, leveraging its innovative DigiWest multiplex protein profiling technology for the identification and validation of diagnostic biomarkers of SOL101. DigiWest is a novel proprietary immunoassay technology that allows simultaneous analyses of hundreds of total and phospho proteins per sample, which has already proven valuable in a number of other lead characterisation and biomarker research projects. Together, the project partners aim to generate a compelling drug-and-diagnostic package that will then be jointly out-licensed to a bigger pharma company.

TT GmbH, added “Knowing the power of our protein profiling approach for biomarker discovery, it is now extremely exciting for us to apply our expertise for addressing the pressing needs of FXS patients”.

About Sentinel Oncology

Sentinel Oncology Ltd. was founded in 2005 in Cambridge, UK, and is a drug discovery company dedicated to the development and commercialisation of novel drug candidates in areas of high unmet medical need. The Sentinel Oncology portfolio includes a lead programme that has been licensed to Oncothyreon Inc. and a second programme that is at the candidate drug phase. We are further developing a suite of novel small molecules designed to enhance therapeutic index by delivering the effects of drugs directly to the tumour. Sentinel Oncology is a fully integrated drug discovery company seeking to develop high quality drug candidates for partnering with the biotechnology and pharmaceutical industry. Our strategy relies on seeking partners and collaborators to maximise the value of our programmes. For more information, please visit www.sentineloncology.com

About NMI TT Pharmaservices

NMI TT Pharmaservices is a preclinical Contract Research Organisation dedicated to provide expert services tocustomers in pharma, biotech, medtech and academia. The company’s business is focused on high-quality services for drug discovery and development, with a long-standing business track record with several top-tier pharma companies, and with a broad portfolio of offerings in multiplex protein profiling, cell & molecular biology, and safety pharmacology. Its novel proprietary DigiWest technology (www.digiwest.de) allows high-content protein profiling of biological samples, and is accessible to life science researchers through fully customizable contract research services. NMI TT GmbH, founded in 2002, is a spin-out of the Natural and Medical Sciences Institute (NMI) at the University of Tübingen, with its headquarters in Reutlingen and a branch in Berlin, Germany. For more information, please visit www.nmi-tt.de/pharmaservices

Contacts

Stuart Travers
COO, Sentinel Oncology
stuart.travers@sentineloncology.com

Dr. Christoph Sachse
Site Head Berlin, NMI TT Pharmaservices
sachse@nmi-tt.de